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Showing posts from March, 2023

Bulbous and Globose-Merkel Cell Carcinoma

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    Open A ccess  Journal of  JOJ Dermatology & Cosmetics  Editorial Merkel cell carcinoma is an infrequently discerned, aggressive, primary cutaneous carcinoma of neuroendocrine origin. Additionally designated as trabecular carcinoma and initially scripted by Toker in 1972, tumefaction simulates numerous benign and malignant cutaneous lesions. Localized disease is common, followed by regional lymph node or distant metastasis. Spontaneous regression of disease is exceptional. Disease-associated mortality is significant [1,2]. Primary cutaneous Merkel cell carcinoma can be segregated from metastatic cutaneous neuroendocrine carcinoma with pertinent clinical and histological examination along with immunohistochemistry. Majority of neoplasms may be engendered due to infection with Merkel cell polyomavirus. Few instances emerge due to ultraviolet radiation induced activation of diverse onco-genetic pathways [1,2]. Generally, elderly Caucasian population >70 years and immunosuppresse

Efficacy of Combined Low-Dose Hormonal Contraceptives in the Treatment of Acne Vulgaris-A Randomized Control Trial Study

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    Open A ccess  Journal of  JOJ Dermatology & Cosmetics   Introduction Acne vulgaris is a skin condition that affects a high number of teenagers and young adults. The pilosebaceous unit is impacted by this multifactorial inflammatory disorder. The understanding of acne pathogenesis is constantly changing. Sebum production, follicular hyper keratinization, complex inflammatory processes, and Propionibacterium acnes microbiological colonization are significant pathogenic elements that contribute to the onset of acne. Acne vulgaris has a substantial physical and psychological morbidity, including low self-esteem, poor self-image, scars, and depression. According to estimates, 12.6% of all dermatological treatment costs in the world go toward treating acne [1]. Due to this and referring the effects of acne and psychological affects to the adolescent it is quite important to focus on new research for efficacity in acne treatment. Aim of the study:  To verify the effectiveness of low-d

Sequential Therapy of Common and Plantar Warts with Salicylic Acid after Cryotherapy Versus Cryotherapy Alone: A Case- Control Study in 42 Subjects

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  Open A ccess  Journal of  JOJ Dermatology & Cosmetics  Abstract Background:  Common wart (CW; Verruca vulgaris) is a benign cutaneous virus infection caused by human papilloma virus commonly located in the palmar and plantar regions. Warts, especially located at pressure points, could be painful, but in general they are asymptomatic. Treatment is not always necessary but when multiple lesions, pain, immunosuppression and discomfort are present therapeutic intervention could be mandatory. Chemical or physical destructions are commonly used for the treatment of CW. Cryotherapy with liquid nitrogen is a common clinician-administered treatment. The most relevant drawbacks of this procedure are the pain associated with treatment, the need of several sessions and the recurrence of new lesion. Salicylic acid (SA) applied under tape occlusion is a convenient, effective, and safe therapy of CW, even if no effective as cryotherapy. So far, there are few data regarding the efficacy and safe