Bulbous and Globose-Merkel Cell Carcinoma
Open A ccess Journal of JOJ Dermatology & Cosmetics Editorial Merkel cell carcinoma is an infrequently discerned, aggressive, primary cutaneous carcinoma of neuroendocrine origin. Additionally designated as trabecular carcinoma and initially scripted by Toker in 1972, tumefaction simulates numerous benign and malignant cutaneous lesions. Localized disease is common, followed by regional lymph node or distant metastasis. Spontaneous regression of disease is exceptional. Disease-associated mortality is significant [1,2]. Primary cutaneous Merkel cell carcinoma can be segregated from metastatic cutaneous neuroendocrine carcinoma with pertinent clinical and histological examination along with immunohistochemistry. Majority of neoplasms may be engendered due to infection with Merkel cell polyomavirus. Few instances emerge due to ultraviolet radiation induced activation of diverse onco-genetic pathways [1,2]. Generally, elderly Caucasian population >70 years and immunosuppresse